Progenics uses the unique, modified double stem cell extraction processing technique developed by Progenics' Research & Development Team (Yang H et al., Transfusion (2011) 51;284-292 and Yang H et al., Transfusion (2015) 55:70-78). The quality is significantly superior to other techniques, regardless of whether they are automated or manual (compared with published information).
Higher Viability of Cells
The viability of transplantable cells (nucleated cells) in the final cord blood product that is banked for future transplant is higher with the double stem cell extraction technique† than with banks using other methods§.
Another critical reason that contributes to a higher viability of cells is that Progenics processes cord blood samples more quickly after collection. The viability of stem cells (CD34+ cells) was 99.43%.
† Yang H et al., Transfusion (2011) 51;284-292
§ Solves P et al., Cytotherapy (2009) 11:1101-1107
Progenics' Research & Development Team works diligently at improving and perfecting the process of cryopreservation of cord blood. In 2015, our findings on how temperature interruptions during controlled-rate-freezing affect the cord blood unit were published in a peer reviewed journal, Transfusion. Furthermore, we discussed procedures to preserve the viability of cord blood stem cells in the event of unexpected temperature interruptions during cryopreservation. This is one of the many advantages of storing your baby's cord blood with Progenics, as cord blood samples are professionally prepared and cryopreserved by technicians with the highest level of training in the field.
Assurance of Secure Long Term Storage
Cord blood is stored in a two-compartment Pall freezing bag that is over-wrapped with another cryobag and stored in an MVE -190ºC vapor (gas) phase freezer.
The freezers containing cord blood samples are stored in a secure, fire-resistant storage facility. The freezers are equipped with a backup power generator to provide power in the event of a power failure. In addition, the storage facility and the temperature in the freezers are monitored 24 hours daily by security and video surveillance. Among the three most commonly used sizes of freezers, Progenics uses the smallest size. If there is ever an emergency, the smaller size of the freezer will require us to transfer fewer cord blood samples from a dysfunctional freezer to a backup freezer and subsequently avoid extra cell damage due to warming. Nevertheless, there is always a backup liquid nitrogen freezer available at our storage facility which can be used immediately to transfer the contents of a dysfunctional freezer.
Validated Quality Assurance
Quality assessment has been validated in previous studies carried out by Progenics' Research and Development Team.
For details see:
Yang H, Loutfy MR, Mayerhofer S, Shuen P. Factors affecting banking quality of umbilical cord blood for transplantation. Transfusion (2011) 51:284-292.
Yang H, Pidgorna A, Loutfy MR, Shuen P. Effects of interruptions of controlled-rate freezing on the viability of umbilical cord blood stem cells. Transfusion (2015) 55:70-78.
In conclusion, should one compare our data with published information from other cord blood banks, one would see that Progenics can store more cells based on our professional and reliable banking process.